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KMID : 1123920120260050672
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Korean Journal of Oriental Physiology and Pathology
2012 Volume.26 No. 5 p.672 ~ p.678
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Improving Effects of Stichopus Japonicus on TNBS-Induced Colitis and Loperamide-Induced Constipation in Animal Disease Models
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Kim Jung-Hoon
Oh Hong-Geun
Kang Young-Rye
Park Jung-Woo
Moon Dae-In
Seo Min-Young
Park Sang-Hoon
Kang Yang-Gyu
Choe Chung-Hyeon
Park In-Sun
Kim-Ju
Yu Kang-Yeol
Kim Jae-Kyoung
Kim Ok-Jin
Hwang Hong-Yeon
Ryu Do-Gon
Lee Yong-Rae
Lee Hak-Yong
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Abstract
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Colitis and constipation are the most common intestinal complaints worldwide. This study examined the beneficial effects of sea cucumber powder for TNBS-induced colitis in ICR mice(n=6/group) and loperamide-induced constipation in rats(n=8/group). Animals were divided into normal and four dried see cucumber treated groups that were named Nor, Con(0 mg/kg), GI(30 mg/kg), GII(100 mg/kg) and GIII(300 mg/kg). In order to induce colitis and constipation, 5% TNBS was injected into distal colon and loperamide (2 mg/kg, twice a day, peroral) was treated for 5 day in the four experimental groups but not the normal group. Gross finding score was decreased tendency by oral administration of sea cucumber in colitis-induced animal model, but colonic weight was not different. Excreted fecal pellet number, weight and water content were increased in the sea cucumber-treated group compared to the non-treated group. The fecal pellet number was reduced within distal colon of the sea cucumber-treated groups. Interestingly, intestinal transit length was increased compared to the non-treated group. Our results demonstrated that colitis and constipation were improved by sea cucumber treatment in the animal models. Specifically, gross finding score in TNBS-induced colitis model was improved by sea cucumber. After animals being fed sea cucumber, excreted fecal number, weight, water contents, and fecal number within distal colon and colonic transit length also get better in loperamide-induced constipation model.
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KEYWORD
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sea cucumber, constipation, loperamide, colitis, trinitrobenzene sulphonic acid
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